Table 3 Association in the subset of 68 subjects with IPF between MUC5B and LCQ scales using full and parsimonious General Linear Models
From: Severity of cough in idiopathic pulmonary fibrosis is associated with MUC5 B genotype
Variable | Independent effect of T allele: F (p-value) | Independent effect of age: F (p-value) | Independent effect of ACE: F (p-value) | Least squares mean for GG genotype | Least squares mean for GT and TT genotypes | Variance explained (R2) |
|---|---|---|---|---|---|---|
Full model (N = 58) | ||||||
Physical | 5.37 (0.03) | 6.06 (0.02) | 3.58 (0.06) | 4.55 | 5.32 | 31.87% |
Psychological | 11.98 (0.001) | 10.77 (0.002) | 4.70 (0.04) | 4.14 | 5.51 | 40.34% |
Social | 11.83 (0.001) | 11.52 (0.001) | 3.76 (0.06) | 4.46 | 5.76 | 42.18% |
Total LCQ | 10.85 (0.002) | 10.60 (0.002) | 4.51 (0.04) | 13.15 | 16.59 | 40.24% |
Parsimonious model (N = 67) | ||||||
Physical | 6.24(0.02) | 8.12 (0.006) | 3.94 (0.05) | 5.00 | 5.70 | 18.58% |
Psychological | 9.53 (0.003) | 9.59 (0.003) | 6.12 (0.02) | 5.10 | 6.15 | 23.80% |
Social | 12.80 (0.007) | 14.35 (0.003) | 4.67 (0.04) | 4.96 | 6.11 | 28.32% |
Total LCQ | 10.56 (0.002) | 11.83 (0.001) | 5.50 (0.02) | 15.07 | 17.95 | 25.68% |