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Table 3 Association in the subset of 68 subjects with IPF between MUC5B and LCQ scales using full and parsimonious General Linear Models

From: Severity of cough in idiopathic pulmonary fibrosis is associated with MUC5 B genotype

Variable Independent effect of T allele: F (p-value) Independent effect of age: F (p-value) Independent effect of ACE: F (p-value) Least squares mean for GG genotype Least squares mean for GT and TT genotypes Variance explained (R2)
Full model (N = 58)
Physical 5.37 (0.03) 6.06 (0.02) 3.58 (0.06) 4.55 5.32 31.87%
Psychological 11.98 (0.001) 10.77 (0.002) 4.70 (0.04) 4.14 5.51 40.34%
Social 11.83 (0.001) 11.52 (0.001) 3.76 (0.06) 4.46 5.76 42.18%
Total LCQ 10.85 (0.002) 10.60 (0.002) 4.51 (0.04) 13.15 16.59 40.24%
Parsimonious model (N = 67)
Physical 6.24(0.02) 8.12 (0.006) 3.94 (0.05) 5.00 5.70 18.58%
Psychological 9.53 (0.003) 9.59 (0.003) 6.12 (0.02) 5.10 6.15 23.80%
Social 12.80 (0.007) 14.35 (0.003) 4.67 (0.04) 4.96 6.11 28.32%
Total LCQ 10.56 (0.002) 11.83 (0.001) 5.50 (0.02) 15.07 17.95 25.68%
  1. Note. Effects of covariates are only noted when they were found to be significant.
  2. Full Model controlled for age, gender, % predicted FVC, GERD status, UACS status, smoking status (yes/no), sleep apnea (yes/no), IPF vs. related diagnosis, and ACE inhibitor (yes/no) (N = 58 due to missing data for the secondary predictors). Only significant predictors are listed.
  3. Parsimonious Model controlled only for significant predictors in the full model: age, gender and ACE inhibitor (yes/no) (N = 67).