Inhibition of TRPV1 polymodal activation by BCTC in HEK293OFF cells. Panel A shows that BCTC antagonizes capsaicin (10 nM) and PMA-mediated (50 nM) activation of gpTRPV1. Panel B shows that inclusion of 100 nM BCTC completely inhibits gpTRPV1 respond to decreases in pH. Data are presented as percent maximal response in the absence of inhibitor (A). Data shown are representative of at least three separate experiments.