Cough and dyspnea during bronchoconstriction: comparison of different stimuli

Cough

Table 1 Characteristics of the subjects studied

Subject	Gender	Age (years)	BMI	FEV₁ (L)	FEV₁ (%)	Tests sequence	PC₂₀ MCh (mg/ml)	PC₂₀ BK (mg/ml)
1	M	23	23.8	3.24	76	BK, EIB, MCh	0.83	2.30
2	M	23	24.2	3.56	83	EIB, BK, MCh	0.21	0.15
3	M	21	24.0	2.98	69	BK, EIB, MCh	0.19	1.16
4	F	30	19.1	3.44	110	MCh, EIB, BK	1.13	3.87
5	F	43	24.8	2.55	83	EIB, MCh, BK	0.56	0.42
6	F	23	25.8	2.26	68	MCh, BK, EIB	0.13	0.58
7	F	45	25.7	2.13	80	EIB, BK, MCh	0.47	1.62
8	F	39	27.9	1.66	54	MCh, BK, EIB	0.14	0.12
9	F	24	33.6	2.81	87	BK, MCh, EIB	0.16	1.17
10	F	38	31.2	2.56	88	BK, MCh, EIB	1.00	0.22
11	M	39	22.1	2.90	74	EIB, MCh, BK	0.62	0.06
12	F	24	32.7	3.16	91	MCh, EIB, BK	0.17	1.16
13	M	24	19.2	3.73	90	EIB, MCh, BK	0.42	1.48
14	M	27	31.8	3.26	77	MCh, BK, EIB	0.28	2.37
15	M	46	26.8	3.29	83	EIB, BK, MCh	0.38	0.71
16	M	33	23.1	3.21	73	BK, MCh, EIB	2.35	2.32
17	F	24	19.6	2.57	80	MCh, EIB, BK	0.95	3.56
18	F	26	21.8	2.30	80	MCh, EIB, BK	0.15	0.20
19	M	38	24.6	2.25	64	BK, MCh, EIB	0.08	0.05
20	M	32	28.7	3.00	80	MCh, BK, EIB	0.58	1.73
Mean		31	25.5	2.84	79.5		0.36^a	0.68^a
SD		8	4.4	0.54	11.6		2.45^b	3.84^b

M: male; F: female; BMI: body mass index; FEV₁: Forced expiratory volume in one second; MCh: methacoline; BK: bradykinin; EIB: exercise-induced bronchospasm; PC₂₀: provocative concentration that results in a 20% fall in FEV₁.
^a geometric mean. ^b geometric standard deviation.