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Table 1 Bronchoalveolar lavage cell analysis

From: Involvement of nitric oxide (NO) in cough reflex sensitivity between non-sensitized and OVA-sensitized guinea pigs

Total cells

(105 cells/mL)

Mac (%)

Neu (%)

Lym (%)

Eos (%)

non-sensitized guinea pigs

   Control

1.11 ± 0.11

71.8 ± 7.1

9.2 ± 5.6

1.8 ± 0.8

16.8 ± 5.6

   ONO1714: 0.1 mg/kg

1.09 ± 0.12

74.5 ± 4.3

6.2 ± 1.5

1.4 ± 0.4

17.9 ± 4.7

   ONO1714: 0.3 mg/kg

0.88 ± 0.09

76.0 ± 2.1

5.3 ± 3.3

1.5 ± 0.5

17.7 ± 1.6

OVA sensitized guinea pigs

   Control

2.63 ± 0.26

24.1 ± 3.1

2.5 ± 0.6

0.9 ± 0.3

72.4 ± 3.1

   ONO1714: 0.1 mg/kg

2.68 ± 0.12

25.1 ± 1.0

2.8 ± 0.3

0.5 ± 0.2

71.6 ± 1.4

   ONO1714: 0.3 mg/kg

2.64 ± 0.36

28.5 ± 3.6

0.8 ± 0.3

0.8 ± 0.3

69.9 ± 3.7

  1. BAL was performed immediately after cough reflex sensitivity in non-sensitized guinea pigs. Whereas in OVA sensitized guinea pigs, BAL was performed 24 h after cough reflex sensitivity. MAC, macrophages; NEU, neutrophils; LYM, lymphocytes; EOS, eosinophils