|
Total cells
|
(105 cells/mL)
|
Mac (%)
|
Neu (%)
|
Lym (%)
|
Eos (%)
|
|---|
|
non-sensitized guinea pigs
|
|
Control
|
1.11 ± 0.11
|
71.8 ± 7.1
|
9.2 ± 5.6
|
1.8 ± 0.8
|
16.8 ± 5.6
|
|
ONO1714: 0.1 mg/kg
|
1.09 ± 0.12
|
74.5 ± 4.3
|
6.2 ± 1.5
|
1.4 ± 0.4
|
17.9 ± 4.7
|
|
ONO1714: 0.3 mg/kg
|
0.88 ± 0.09
|
76.0 ± 2.1
|
5.3 ± 3.3
|
1.5 ± 0.5
|
17.7 ± 1.6
|
|
OVA sensitized guinea pigs
|
|
Control
|
2.63 ± 0.26
|
24.1 ± 3.1
|
2.5 ± 0.6
|
0.9 ± 0.3
|
72.4 ± 3.1
|
|
ONO1714: 0.1 mg/kg
|
2.68 ± 0.12
|
25.1 ± 1.0
|
2.8 ± 0.3
|
0.5 ± 0.2
|
71.6 ± 1.4
|
|
ONO1714: 0.3 mg/kg
|
2.64 ± 0.36
|
28.5 ± 3.6
|
0.8 ± 0.3
|
0.8 ± 0.3
|
69.9 ± 3.7
|
- BAL was performed immediately after cough reflex sensitivity in non-sensitized guinea pigs. Whereas in OVA sensitized guinea pigs, BAL was performed 24 h after cough reflex sensitivity. MAC, macrophages; NEU, neutrophils; LYM, lymphocytes; EOS, eosinophils
