Study | Sample Size | Design | Disease | Results |
---|---|---|---|---|
Eccles R, et al. Lack of effect of codeine in the treat- ment of cough associated with acute upper respiratory tract infection. Journal of Clinical Pharmacy and Therapeutics 1992;17(3):175-80. | 81 adults | Not reported | URTI's | Codeine was no more effective than placebo either as a single dose or in a total daily dose of 120 mg, reported on a five-point cough severity score (P > 0.2). |
Freestone C et al. Assessment of the antitussive efficacy of codeine in cough associated with common cold. Journal of Pharmacy and Pharmacology 1997;49:1045-9. | 82 adults | A double-blind, stratified, placebo-controlled, parallel-group, | URTI's | The results demonstrate that codeine is no more effective than placebo in reducing cough associated with acute URTI, as measured by CSPLs, cough frequency or subjective symptom scores |