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Table 1 Clinical Studies with Codeine

From: Cough management: a practical approach

Study Sample Size Design Disease Results
Eccles R, et al. Lack of effect of codeine in the treat-
ment of cough associated with acute upper respiratory tract infection.
Journal of Clinical Pharmacy and Therapeutics 1992;17(3):175-80.
81 adults Not reported URTI's Codeine was no more effective
than placebo either as a single dose or in a total daily dose of
120 mg, reported on a five-point cough severity score (P > 0.2).
Freestone C et al. Assessment of the antitussive efficacy of codeine in cough associated with common cold. Journal of Pharmacy
and Pharmacology 1997;49:1045-9.
82 adults A double-blind, stratified, placebo-controlled, parallel-group, URTI's The results demonstrate that codeine is no more effective than placebo in reducing cough associated with acute URTI, as measured by CSPLs, cough frequency or subjective symptom scores