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Table 2 Clinical Studies with Dextromethorphan

From: Cough management: a practical approach

Study Sample Size Design Disease Results
Lee PCL et al. Antitussive efficacy dextromethorphan in cough associated with acute upper respiratory in-
fection. Journal of Pharmacy and Pharmacology 2000;52:1137-42.
44 adults A double-blind, stratified, randomized and parallel group design URTI's This study provides very little if any support for clinically significant antitussive activity of a single 30 mg dose of dextromethorphan in patients with cough associated with URTI's
Parvez L, et al Evaluation of antitussive agents in man. Pulmonary Pharmacology
1996;9(5-6):299-308.
451 adults Review of three different studies randomized, double blind, placebo controlled URTI's The results establish the sensitivity and robustness of the cough quantization methodology in the objective evaluation of cough treatments
Pavesi L et al. Application and validation of a
computerized cough acquisition system for objective monitoring of
acute cough: a meta-analysis. Chest 001;120:1121-8.
710 adults Six studies used for the meta-analysis were randomized, double-blind, parallel-group, single-dose, placebo-controlled studies with a 3-h postdose cough evaluation period URTI's The results of a meta-analysis show that the antitussive effect of a single dose of dextromethorphan hydrobromide, 30 mg, has been established.