Lee PCL et al. Antitussive efficacy dextromethorphan in cough associated with acute upper respiratory in-|
fection. Journal of Pharmacy and Pharmacology 2000;52:1137-42.
|44 adults||A double-blind, stratified, randomized and parallel group design||URTI's||This study provides very little if any support for clinically significant antitussive activity of a single 30 mg dose of dextromethorphan in patients with cough associated with URTI's|
Parvez L, et al Evaluation of antitussive agents in man. Pulmonary Pharmacology|
|451 adults||Review of three different studies randomized, double blind, placebo controlled||URTI's||The results establish the sensitivity and robustness of the cough quantization methodology in the objective evaluation of cough treatments|
Pavesi L et al. Application and validation of a|
computerized cough acquisition system for objective monitoring of
acute cough: a meta-analysis. Chest 001;120:1121-8.
|710 adults||Six studies used for the meta-analysis were randomized, double-blind, parallel-group, single-dose, placebo-controlled studies with a 3-h postdose cough evaluation period||URTI's||The results of a meta-analysis show that the antitussive effect of a single dose of dextromethorphan hydrobromide, 30 mg, has been established.|