Table 3 Clinical Studies with Levodropropizine vs Central antitussives in adults
Study | Sample Size | Design | Disease | Results |
|---|---|---|---|---|
Allegra et al. Arneim. Forsch./Drug Res., vol. 38 (II) 8: 1163-6, 1988. | 174 adults | The studies have been conducted as follow: 1-2 Studies: vs Placebo 3-4 Studies: vs Morclofone 1% 5-6 studies: Cloperastine drops 2% | Bronchitis | - LDP antitussive action resulted in being higher than placebo and morclofone and similar to cloperastin. - LDP showed effective in about 80% patients: in responders the cough frequency was reduced by 33-51%. |
Catena. et al. Pulmonary Pharmacology & Therapeutics 1997; 10: 89-96. | 209 adults | Double blind randomized vs Dextromethorphan | Non productive cough | - The results bear out the effectiveness of LDP as an antitussive comparable with dextromethorphan - The results support a less incidence of somnolence and nightly awakenings in the LDP's group |
Luporini G. et al Eur Respir J 1998; 12: 97-101 | 140 adults | Double blind randomized vs Dihydrocodeine | Lung Tumor | - The antitussive effect of LDP was comparable with the reference drug, Dihydrocodeine. LDP induced significantly less somnolence compared to Dihydrocodeine. |