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Table 1 Characteristics of the subjects.

From: Cough response to isocapnic hyperpnoea of dry air and hypertonic saline are interrelated

  Asthma Healthy control p
n 36 14  
Gender (male/female) 10/26 2/12  
Age 40 (18-68) 37 (21-67)  
Atopy# 22 5  
Smoking (mean pack years)    
Current 9 (6) 0  
Previous 3 (11) 0  
Use of inhaled corticosteroids (ICS) 24 0  
Daily dose of ICS 541 ± 391 μg -  
ASA intolerance 3 0  
Use of ACE inhibitors 5 0  
Exhaled nitric oxide 18.4 ± 15.0 14.6 ± 6.59 0.376
FEV1 (% from predicted) 90.0 (67-122) 92.8 (78-110) 0.418
Mean daily PEF variability (%) 7.90 ± 5.75 -  
Needed rescue medication doses during pre-test week 0.83 (0-4) -  
CDR Hypertonic saline coughs/(mOsm/kg) 0.012 ± 0.010 0 <0.001
CDR Hyperpnoea of dry air coughs/MVV% 0.464 ± 0.514 0.011 ± 0.024 <0.001
  1. Age, FEV1 and needed rescue medication doses mean (range). # Atopy was assessed as ≥3 mm mean wheal diameter in the skin prick test to at least one common aeroallergen. Daily dose of ICS, exhaled NO, mean daily PEF variability and CDR (cough-to-dose ratio) mean ± SD. Reference values are those of Viljanen et al. [34]