Review: Effect of drugs on human cough reflex sensitivity to inhaled capsaicin

Cough

Table 1 Drugs shown to inhibit cough reflex sensitivity to capsaicin

1^stauthor	Ref. #	Year	Drug	Subject population
Wise P	[5]	2012	menthol	healthy volunteers
Takemura M	[6]	2012	montelukast	cough-variant asthma
Ekstrand Y	[7]	2011	inhaled steroids	asthma
Ishiura Y	[8]	2010	etodolac	sinobronchial syndrome
Ishiura Y	[9]	2009	etodolac	asthma
Dicpinigaitis P	[10]	2009	guaifenesin	viral URI
Davenport P	[11]	2009	nicotine	healthy smokers
Dicpinigaitis P	[12]	2008	tiotropium	viral URI
Ishiura Y	[13]	2008	suplatast	atopic cough
Ferrari M	[14]	2007	omeprazole	asthma + GERD
Usmani O	[15]	2005	theobromine	healthy volunteers
Shioya T	[16]	2004	epinastine	atopic cough
Dicpinigaitis P	[17]	2003	guaifenesin	viral URI
Ishiura Y	[18]	2003	carbocysteine	asthma
Ishiura Y	[19]	2003	seratrodast	chronic bronchitis
Shioya T	[20]	2002	suplatast	cough-variant asthma
Dicpinigaitis P	[21]	2002	zafirlukast	cough-variant asthma
Ceyhan B	[22]	2002	oxolamine	COPD
Dicpinigaitis P	[23]	2000	baclofen	cervical SCI
Brightling C	[24]	2000	budesonide	eosinophilic bronchitis
Dicpinigaitis P	[25]	1998	baclofen	healthy volunteers
Shioya T	[26]	1998	azelastine	asthma
Dicpinigaitis P	[27]	1997	baclofen	healthy volunteers
Shioya T	[28]	1996	azelastine	cough-variant asthma
Fujimura M	[29]	1995	indomethacin	asthma, chronic bronchitis
Hargreaves M	[30]	1995	sodium cromoglycate	ACE-inhibitor cough
Hansson L	[31]	1994	lignocaine	healthy volunteers
Van Wyck M	[32]	1994	glycopyrrolate	ACE-inhibitor cough
Cazzola M	[33]	1993	theophylline	ACE-inhibitor cough
Foster G	[34]	1991	sulindac	healthy volunteers
McEwan J	[35]	1990	sulindac	ACE-inhibitor cough
Choudry N	[36]	1990	lignocaine	healthy volunteers
Fuller R	[37]	1988	codeine,morphine	healthy volunteers

Abbreviations: URI-acute upper respiratory tract infection; GERD-gastroesophageal reflux disease; SCI-spinal cord injury; ACE-angiotensin-converting enzyme.