Cough

Table 3 Values of cough reflex sensitivity obtained in TRPM8 line of the study

From: Modulation of cough response by sensory inputs from the nose - role of trigeminal TRPA1 versus TRPM8 channels

	Saline	Vehicle	(+) Menthol	(−) Menthol
C2
Cu	11.8	12.7	26.5 *	22.4*
C2 GM	12.5	14.7	31.3 *	26.3*
GSD	4.6	2.7	5.9	6.1
CI min	10.4	11.3	28.9	23.8
CI max	14.7	17.2	33.6	28.7
C5
GM	261	249	458.5	478.8
GSD	4	4.3	3.1	2.9
CI min	259	248	456.8	477
CI max	263	251	460.2	480.5

Note: data are expressed in μM, GM – geometric mean, GSD – geometric standard deviation, CI min, CI max – 95% confidence intervals with alpha = 0.05. *p<0.05, Cu – urge to cough, C2 – concentration of capsaicin inducing 2 or more coughs, C5 concentration of capsaicin inducing 5 or more coughs.

Back to article page