| |
%Animals Coughing to Citric Acid
|
|---|
|
Treatment
|
n
|
Time to 1st Cough (min)
|
-P Pressures (%control)
|
0.01M
|
0.1M
|
|---|
|
Vehicle control
|
15
|
2.0±03
|
1144±102%
|
27% (4/ 15)
|
93% (14/ 15)
|
|
0.3 mg/ kg baclofen
|
3
|
2.4±0.6
|
837±187%
|
100% (3/ 3)
|
100% (3/ 3)
|
|
3 mg/ kg baclofen
|
6
|
1.4±0.3
|
705±110%
|
0% (0/ 6)*
|
50% (3/ 6)
|
|
3 mg/ kg SKF97541
|
5
|
2.7±1.0
|
852±92%
|
0% (0/ 5)*
|
60% (3/ 5)
|
|
0.3 mg/ kg 3-APPiA
|
4
|
2.8±0.7
|
762±121%
|
0% (0/ 5)*
|
80% (4/ 5)
|
|
3 mg/ kg 3-APPiA
|
7
|
3.3±0.7
|
986±120%
|
0% (0/ 7)*
|
57% (4/ 7)
|
|
1 mg/ kg lesogaberan
|
5
|
1.7±0.2
|
1426±142%
|
0% (0/ 5)*
|
80% (4/ 5)
|
|
3 mg/ kg lesogaberan
|
8
|
2.1±0.6
|
1100±144%
|
13% (1/ 8)
|
63% (5/ 8)
|
|
10 mg/ kg lesogaberan
|
8
|
3.0±0.6
|
855±99%
|
0% (0/ 8)*
|
50% (4/ 8)
|
- The data are presented as the %animals coughing or as the mean ± sem of n experiments where n is a single animal studied in a non paired experimental design. The time to first cough was measured during challenges with 0.3 M citric acid. The peak to peak (P-P) pressures associated with cough were measured for the first 5 coughs evoked during challenge, regardless of citric acid concentration. An asterisk (*) indicates a statistically significant difference from that observed in vehicle treated animals (p < 0.05).
