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Table 1 Effects of GABA B agonists on the percentage of animals coughing, time to onset of coughing and on peak expiratory pressures during cough

From: Antitussive effects of the peripherally restricted GABAB receptor agonist lesogaberan in guinea pigs: comparison to baclofen and other GABABreceptor-selective agonists

  %Animals Coughing to Citric Acid
Treatment n Time to 1st Cough (min) -P Pressures (%control) 0.01M 0.1M
Vehicle control 15 2.0±03 1144±102% 27% (4/ 15) 93% (14/ 15)
0.3 mg/ kg baclofen 3 2.4±0.6 837±187% 100% (3/ 3) 100% (3/ 3)
3 mg/ kg baclofen 6 1.4±0.3 705±110% 0% (0/ 6)* 50% (3/ 6)
3 mg/ kg SKF97541 5 2.7±1.0 852±92% 0% (0/ 5)* 60% (3/ 5)
0.3 mg/ kg 3-APPiA 4 2.8±0.7 762±121% 0% (0/ 5)* 80% (4/ 5)
3 mg/ kg 3-APPiA 7 3.3±0.7 986±120% 0% (0/ 7)* 57% (4/ 7)
1 mg/ kg lesogaberan 5 1.7±0.2 1426±142% 0% (0/ 5)* 80% (4/ 5)
3 mg/ kg lesogaberan 8 2.1±0.6 1100±144% 13% (1/ 8) 63% (5/ 8)
10 mg/ kg lesogaberan 8 3.0±0.6 855±99% 0% (0/ 8)* 50% (4/ 8)
  1. The data are presented as the %animals coughing or as the mean ± sem of n experiments where n is a single animal studied in a non paired experimental design. The time to first cough was measured during challenges with 0.3 M citric acid. The peak to peak (P-P) pressures associated with cough were measured for the first 5 coughs evoked during challenge, regardless of citric acid concentration. An asterisk (*) indicates a statistically significant difference from that observed in vehicle treated animals (p < 0.05).