Antitussive effects of the peripherally restricted GABAB receptor agonist lesogaberan in guinea pigs: comparison to baclofen and other GABABreceptor-selective agonists

Cough

Table 1 Effects of GABA _B agonists on the percentage of animals coughing, time to onset of coughing and on peak expiratory pressures during cough

				%Animals Coughing to Citric Acid
Treatment	n	Time to 1^st Cough (min)	-P Pressures (%control)	0.01M	0.1M
Vehicle control	15	2.0±03	1144±102%	27% (4/ 15)	93% (14/ 15)
0.3 mg/ kg baclofen	3	2.4±0.6	837±187%	100% (3/ 3)	100% (3/ 3)
3 mg/ kg baclofen	6	1.4±0.3	705±110%	0% (0/ 6)*	50% (3/ 6)
3 mg/ kg SKF97541	5	2.7±1.0	852±92%	0% (0/ 5)*	60% (3/ 5)
0.3 mg/ kg 3-APPiA	4	2.8±0.7	762±121%	0% (0/ 5)*	80% (4/ 5)
3 mg/ kg 3-APPiA	7	3.3±0.7	986±120%	0% (0/ 7)*	57% (4/ 7)
1 mg/ kg lesogaberan	5	1.7±0.2	1426±142%	0% (0/ 5)*	80% (4/ 5)
3 mg/ kg lesogaberan	8	2.1±0.6	1100±144%	13% (1/ 8)	63% (5/ 8)
10 mg/ kg lesogaberan	8	3.0±0.6	855±99%	0% (0/ 8)*	50% (4/ 8)

The data are presented as the %animals coughing or as the mean ± sem of n experiments where n is a single animal studied in a non paired experimental design. The time to first cough was measured during challenges with 0.3 M citric acid. The peak to peak (P-P) pressures associated with cough were measured for the first 5 coughs evoked during challenge, regardless of citric acid concentration. An asterisk (*) indicates a statistically significant difference from that observed in vehicle treated animals (p < 0.05).