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Table 1 Characteristics of the 10 patients with CIC

From: Clinical experience with low-dose itraconazole in chronic idiopathic cough

Case 1 2 3 4 5 6 7 8 9 10
Age (yr) 63 70 68 69 67 55 62 71 47 63
Gender M F M F F M F F F F
Smoking ex-smoker never never never never never never never never never
Duration (Month) 49 68 66 70 44 64 48 27 41 62
WBC 4350 5800 8100 5600 5900 6600 4000 4900 3000 5400
Eo (%) 2.4 5.2 1.1 1.7 1.1 0 1.4 1 3.2 1.7
IgE (IU/ml) 179 20 97 119 734 75.5 16 38 20 29
FVC 2.78(81.0) 2.64(118.9) 4.67(137.0) 2.46(108.4) 3.46(149.8) 3.70(98.9) 2.94(126.2) 2.69(123.4) 2.95(110.5) 2.17(87.1)
FEV1 2.13(80.1) 1.90(118.7) 3.62(138.2) 1.93(114.9) 2.69(152.0) 3.07(96.5) 2.56(143.0) 2.20(144.7) 2.53(106.3) 1.67(80.7)
FEV1/FVC (%) 76.6 72 77.5 78.5 77.7 83 87.1 81.8 85.8 77
Reversibility (%) 1.2 2.6 −3.6 5.7 3.7 1.3 0.4 0.9 5.9 2.4
Rt-Meth (mg/mL) 20000< 20000< 20000< 20000< 20000< 20000< 5000 20000< 20000< 20000<
Cough (μM) 0.98 31.3 62.5 31.3 1.95 15.6 3.91 0.49 0.49 1.95
  1. Eo: Eosinophil. FEV1: forced expiratory volume in 1 s. FEV1%: the ratio of forced expiratory volume in is (FEV1) to forced vital capacity (FVC). RT-Meth: respiratory threshold of methacholine (mg/ml) required to cause a 20% or more fall in FEV1 from the baseline value. Cough: The capsaicin cough threshold (C5) was defined as the lowest concentration of inhaled capsaicin eliciting five or more coughs.