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Table 3 Changes in domains of J-LCQ in 10 patients with CIC pre- and post-low-dose ITCZ therapy

From: Clinical experience with low-dose itraconazole in chronic idiopathic cough

   pre- post-     pre- post-     pre- post-     pre- post-     pre- post-   
Case 1      2      3      4      5     
J-LCQ                          
 total   14.29 15.92 1.63 *   16.13 16.61 0.48    18.63 17.61 −1.02    14.84 16.71 1.87 *   16.71 18.02 1.31 *
 physical   4.75 6.13 1.38 *   4.63 5.25 0.62 *   5.38 5.5 0.12    5.13 5.5 0.37 *   5 5.5 0.5 *
 social   4.25 4.5 0.25 *   5.5 5.5 0    6.25 6.25 0    5 5.5 0.5 *   6 6.5 0.5 *
 psychological   5.29 5.29 0    6 5.86 −0.14    7 5.86 −1.14    4.71 5.71 1 *   5.71 6.02 0.31  
Cough VAS (mm)   30 26 −4 *   22 24 2    17 32 15    10 8 −2    74 58 −16 *
Cough No.   3 4 1    9 7 −2    7 8 1    3 3 0    6 6 0  
Case 6      7      8      9      10     
J-LCQ                          
 total   18.92 16.81 −2.11    17.95 17.52 −0.43    19.59 20.5 0.91    8.32 12.96 4.64 *   16.2 20.63 4.43 *
 physical   6.13 5.63 −0.5    5.63 5.38 −0.25    6.38 6.5 0.12    3.25 4 0.75 *   5.13 6.88 1.75 *
 social   6.5 5.75 −0.75    5.75 6 0.25 *   6.5 7 0.5 *   2.5 4.25 1.75 *   5.5 6.75 1.25 *
 psychological   6.29 5.43 −0.86    6.57 6.14 −0.43    6.71 7 0.29    2.57 4.71 2.14 *   5.57 7 1.43 *
Cough VAS (mm)   39 44 5    34 26 −8    18 30 12    52 31 −21 *   61 43 −18 *
Cough No.   7 7 0    4 4 0    2 9 7 *   3 4 1    5 4 −1  
  1. The mean MID of the J-LCQ corresponding to a small change in the four GRCQ score was 1.3. The MIDs for domains were as follows: physical 0.2, social 0.2, and psychological 0.8. A change in cough scale by more than 15 mm was taken to be significant. * Significant improvement in each MID of J-LCQ, Cough VAS after the low dose ITCZ therapy.