Clinical experience with low-dose itraconazole in chronic idiopathic cough

Cough

Table 3 Changes in domains of J-LCQ in 10 patients with CIC pre- and post-low-dose ITCZ therapy

		pre-	post-				pre-	post-				pre-	post-				pre-	post-				pre-	post-
Case	1					2					3					4					5
J-LCQ
total		14.29	15.92	1.63	*		16.13	16.61	0.48			18.63	17.61	−1.02			14.84	16.71	1.87	*		16.71	18.02	1.31	*
physical		4.75	6.13	1.38	*		4.63	5.25	0.62	*		5.38	5.5	0.12			5.13	5.5	0.37	*		5	5.5	0.5	*
social		4.25	4.5	0.25	*		5.5	5.5	0			6.25	6.25	0			5	5.5	0.5	*		6	6.5	0.5	*
psychological		5.29	5.29	0			6	5.86	−0.14			7	5.86	−1.14			4.71	5.71	1	*		5.71	6.02	0.31
Cough VAS (mm)		30	26	−4	*		22	24	2			17	32	15			10	8	−2			74	58	−16	*
Cough No.		3	4	1			9	7	−2			7	8	1			3	3	0			6	6	0
Case	6					7					8					9					10
J-LCQ
total		18.92	16.81	−2.11			17.95	17.52	−0.43			19.59	20.5	0.91			8.32	12.96	4.64	*		16.2	20.63	4.43	*
physical		6.13	5.63	−0.5			5.63	5.38	−0.25			6.38	6.5	0.12			3.25	4	0.75	*		5.13	6.88	1.75	*
social		6.5	5.75	−0.75			5.75	6	0.25	*		6.5	7	0.5	*		2.5	4.25	1.75	*		5.5	6.75	1.25	*
psychological		6.29	5.43	−0.86			6.57	6.14	−0.43			6.71	7	0.29			2.57	4.71	2.14	*		5.57	7	1.43	*
Cough VAS (mm)		39	44	5			34	26	−8			18	30	12			52	31	−21	*		61	43	−18	*
Cough No.		7	7	0			4	4	0			2	9	7	*		3	4	1			5	4	−1

The mean MID of the J-LCQ corresponding to a small change in the four GRCQ score was 1.3. The MIDs for domains were as follows: physical 0.2, social 0.2, and psychological 0.8. A change in △ cough scale by more than 15 mm was taken to be significant. * Significant improvement in each MID of J-LCQ, Cough VAS after the low dose ITCZ therapy.