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Table 3 Associations of the baseline test results with the magnitude and the speed of the budesonide response (N = 39)

From: Capability of hypertonic saline cough provocation test to predict the response to inhaled corticosteroids in chronic cough: a prospective, open-label study

 

Magnitude of the response

Speed of the response

Saline CDR

Rs = -0.09, p = 0.59

Rs = 0.12, p = 0.45

Nitric oxide level

Rs = 0.37, p = 0.020

Rs = -0.31, p = 0.055

Histamine RDRa

Rs = 0.47, p = 0.003

Rs = -0.49, p = 0.002

FEV1

Rs = -0.16, p = 0.32

Rs = 0.23, p = 0.17

FEV1 rise after salbutamol

Rs = 0.10, p = 0.55

Rs = -0.12, p = 0.48

Mean PEF variation

Rs = 0.18, p = 0.28

Rs = -0.21, p = 0.19

  1. a Histamine challenge was missed in one subject due to technical reasons.
  2. Rs Spearman correlation coefficient.
  3. Magnitude of the response was defined as the maximal improvement in LCQ total score at any stage of the treatment. Speed of the response was defined as the time in weeks from the start of budesonide treatment to the appearance of minimal important change in LCQ total score.