Table 1 Activators and modulators of itch and cough pathways
From: Molecular signaling and targets from itch: lessons for cough
Agent | Pathway | Evoke Itch | Evoke Cough |
|---|---|---|---|
Bradykinin | B1, B2 | Weakly, modulator | Yes, modulator |
Capsaicin | TRPV1 | superficial application, Yes, modulator | Yes |
Oxidative | TRPA1 | Yes | Yes, modulator |
Cowhage | PAR2, PAR4 | Yes | Yes |
Histamine | H1, H4 | Yes, modulator | Modulator |
Proteases | PAR1, PAR2, PAR4 | Yes | Modulator |
Serotonin | 5HT2, 5HT3 | Yes | Modulator |
Substance P | NK1, NK2 | Yes | Modulator |