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Table 1 Activators and modulators of itch and cough pathways

From: Molecular signaling and targets from itch: lessons for cough

Agent Pathway Evoke Itch Evoke Cough
Bradykinin B1, B2 Weakly, modulator Yes, modulator
Capsaicin TRPV1 superficial application, Yes, modulator Yes
Oxidative TRPA1 Yes Yes, modulator
Cowhage PAR2, PAR4 Yes Yes
Histamine H1, H4 Yes, modulator Modulator
Proteases PAR1, PAR2, PAR4 Yes Modulator
Serotonin 5HT2, 5HT3 Yes Modulator
Substance P NK1, NK2 Yes Modulator