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Table 2 Study assessments and timetable

From: A crossover randomized comparative study of zofenopril and ramipril on cough reflex and airway inflammation in healthy volunteers

  1st treatment period Wash-out 2nd treatment period
Day(s) 1 2 3 4 5 6 7 8-29(±2) 30 31 32 33 34 35 36
Drug dosing x x x x x x x   x x x x x x x
Vital signs recordings x       x   x       x
Capsaicin and citric acid challenges x       x   x       x
Spontaneous cough recordings at home From day 1 to 7   From day 30 to 36
FeNO measurementa x       x   x       x
Assessment of pre-dose PK parameters x   x   x x x   x   x   x x x
Assessment of post-dose PK parametersb        x         x
Pre-dose BK measurements x       x   x       x
Post-dose BK measurementsc        x         x
AE monitoring From day 1 to 7    From day 30 to 36
  1. FeNO, fractional exhaled nitric oxide; AE, adverse event; PK, pharmacokinetic; BK, bradykinin; a FeNO assessments were performed at pre-dose, 1.5 h and 5.5 h post-dose; bBlood samples obtained 20', 40', 1 h, 1 h30', 2 h, 3 h, 4 h, 5 h, 6 h, 8 h, 10 h, 12 h, 16 h, 24 h after drug administration; c measurement performed 40', 1 h, 2 h, 4 h, 6 h, 10 h, 16 h, and 24 h after drug administration.