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  1. Content type: Review

    Cough is one of the most common symptoms for which patients seek medical attention from primary care physicians and pulmonologists. Cough is an important defensive reflex that enhances the clearance of secreti...

    Authors: Francesco De Blasio, Johann C Virchow, Mario Polverino, Alessandro Zanasi, Panagiotis K Behrakis, Gunsely Kilinç, Rossella Balsamo, Gianluca De Danieli and Luigi Lanata

    Citation: Cough 2011 7:7

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  2. Content type: Research

    Chronic cough is a common condition, but some patients have no evident medical explanation for their symptoms. A group of patients has been identified, characterized by upper and lower airway symptoms triggere...

    Authors: Ewa Ternesten-Hasséus, Sven Larsson and Eva Millqvist

    Citation: Cough 2011 7:6

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  3. Content type: Research

    Exhaled nitric oxide (ENO) is elevated in bronchial asthma patients, and inhaled corticosteroid therapy lowers the elevated ENO levels in such patients. ENO appears to be an inflammatory marker, but its role i...

    Authors: Akihiro Hori, Masaki Fujimura, Noriyuki Ohkura and Akira Tokuda

    Citation: Cough 2011 7:5

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  4. Content type: Research

    Acute cough has a significant impact on physical and psychosocial health and is associated with an impaired quality of life (QOL). The Leicester Cough Questionnaire (LCQ) is a validated cough-related health st...

    Authors: Nadia Yousaf, Kai K Lee, Bhagyashree Jayaraman, Ian D Pavord and Surinder S Birring

    Citation: Cough 2011 7:4

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  5. Content type: Research

    The effect of aging on the cognitive aspect of cough has not been studied yet. The purpose of this study is to investigate the aging effect on the perception of urge-to-cough in healthy individuals.

    Authors: Satoru Ebihara, Takae Ebihara, Masashi Kanezaki, Peijun Gui, Miyako Yamasaki, Hiroyuki Arai and Masahiro Kohzuki

    Citation: Cough 2011 7:3

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  6. Content type: Research

    Patients with idiopathic pulmonary fibrosis (IPF) frequently develop a dry, irritating cough which often proves refractory to anti-tussive therapies. The precise pathogenetic mechanisms responsible for this co...

    Authors: Richard M Jones, Simon Hilldrup, Benjamin DM Hope-Gill, Ronald Eccles and Nicholas K Harrison

    Citation: Cough 2011 7:2

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  7. Content type: Review

    Cough is a common and distressing symptom in lung cancer patients. The clinical management of cough in lung cancer patients is suboptimal with limited high quality research evidence available. The aim of the p...

    Authors: Alex Molassiotis, Jaclyn A Smith, Mike I Bennett, Fiona Blackhall, David Taylor, Burhan Zavery, Amelie Harle, Richard Booton, Elaine M Rankin, Mari Lloyd-Williams and Alyn H Morice

    Citation: Cough 2010 6:9

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  8. Content type: Research

    Sinobronchial syndrome is a cause of chronic productive cough. Inflammatory mediators are involved in the pathophysiology of chronic productive cough. Accumulating evidences indicate that cyclooxygenase (COX)-...

    Authors: Yoshihisa Ishiura, Masaki Fujimura, Hiroki Yamamoto, Noriyuki Ohkura and Shigeharu Myou

    Citation: Cough 2010 6:7

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  9. Content type: Case report

    A 62-year-old man presented with chronic dry cough. He was known to have Crohn's disease which was in remission. A plain chest radiograph demonstrated bilateral apical infiltrates. A HRCT of the chest showed n...

    Authors: Shoaib Faruqi, Ged Avery and Alyn H Morice

    Citation: Cough 2010 6:6

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  10. Content type: Research

    Cough is a common presenting symptom in patients with Idiopathic Pulmonary Fibrosis (IPF). This study measured cough rates in IPF patients and investigated the association between cough and measures of health ...

    Authors: Angela L Key, Kimberley Holt, Andrew Hamilton, Jaclyn A Smith and John E Earis

    Citation: Cough 2010 6:4

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  11. Content type: Methodology

    While cough is an important defence mechanism of the respiratory system, its chronic presence is bothersome and may indicate the presence of a serious disease. We hereby describe the validation process of a no...

    Authors: Eldad Vizel, Mordechai Yigla, Yulia Goryachev, Eyal Dekel, Vered Felis, Hanna Levi, Isaac Kroin, Simon Godfrey and Noam Gavriely

    Citation: Cough 2010 6:3

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  12. Content type: Research

    Although cigarette smoking has been implicated as an important risk factor for the development of respiratory symptoms, the perceptional aspects of two symptoms in smokers have not been fully elucidated. There...

    Authors: Masashi Kanezaki, Satoru Ebihara, Etsuhiro Nikkuni, Peijun Gui, Chihiro Suda, Takae Ebihara, Miyako Yamasaki and Masahiro Kohzuki

    Citation: Cough 2010 6:1

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  13. Content type: Research

    The purpose of this study was to identify the spatiotemporal determinants of the cough motor pattern. We speculated that the spatial and temporal characteristics of the cough motor pattern would be regulated s...

    Authors: Cheng Wang, Sourish Saha, Melanie J Rose, Paul W Davenport and Donald C Bolser

    Citation: Cough 2009 5:12

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  14. Content type: Research

    Although chronic cough is a common problem in clinical practice, data on the prevalence and characteristics of cough in the general population are scarce. Our aim was to determine the prevalence of chronic cou...

    Authors: Robert J Adams, Sarah L Appleton, David H Wilson, Anne W Taylor and Richard E Ruffin

    Citation: Cough 2009 5:10

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  15. Content type: Review

    Acute cough is one of the most common complaints prompting patient visits to healthcare professionals. Despite the broad repercussions of acute cough on patient quality of life, school and work productivity, a...

    Authors: Peter V Dicpinigaitis, Gene L Colice, Mary Jo Goolsby, Gary I Rogg, Sheldon L Spector and Birgit Winther

    Citation: Cough 2009 5:11

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  16. Content type: Research

    Cough in the patients with cough variant asthma is triggered by bronchoconstriction, which responds to bronchodilator therapy. Following airway narrowing induced by inhaled methacholine, deep inspiration (DI) ...

    Authors: Noriyuki Ohkura, Masaki Fujimura, Akira Tokuda, Johsuke Hara, Akihiro Hori, Masaru Nishitsuji, Miki Abo and Nobuyuki Katayama

    Citation: Cough 2009 5:9

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  17. Content type: Research

    Involuntary cough is a classic symptom of many respiratory diseases. The act of coughing serves a variety of functions such as clearing the airways in response to respiratory irritants or aspiration of foreign...

    Authors: Ayman A Abaza, Jeremy B Day, Jeffrey S Reynolds, Ahmed M Mahmoud, W Travis Goldsmith, Walter G McKinney, E Lee Petsonk and David G Frazer

    Citation: Cough 2009 5:8

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  18. Content type: Research

    Little is known regarding mechanistic and phenotypic differences between cough variant asthma (CVA), presenting with a chronic cough as the sole symptom that responds to bronchodilators, and classic asthma wit...

    Authors: Hisako Matsumoto, Akio Niimi, Masaya Takemura, Tetsuya Ueda, Masafumi Yamaguchi, Hirofumi Matsuoka, Makiko Jinnai, Kazuo Chin and Michiaki Mishima

    Citation: Cough 2009 5:3

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  19. Content type: Research

    The down-regulation of the cough reflex in patients with aspiration pneumonia can involve both cortical facilitatory pathways for cough and medullary reflex pathways. In order to study the possible involvement...

    Authors: Shinsuke Yamanda, Satoru Ebihara, Takae Ebihara, Miyako Yamasaki, Takaaki Asamura, Masanori Asada, Kaori Une and Hiroyuki Arai

    Citation: Cough 2008 4:11

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  20. Content type: Case report

    Achalasia is a rare motility disorder of the esophagus which results from lack of enervation of the lower esophageal sphincter muscles and leads to dilatation of proximal esophagus. Patients with achalasia pre...

    Authors: Nighat F Mehdi, Miles M Weinberger and Mutasim N Abu-Hasan

    Citation: Cough 2008 4:6

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  21. Content type: Case report

    A 15-year-old girl was referred with a 2-year history of perennial non-productive cough, which had been preceded by Mycoplasma pneumoniae pneumonia and subsequent asthma. Symptoms were only partially responsive t...

    Authors: Makiko Jinnai, Akio Niimi, Masaya Takemura, Hisako Matsumoto, Yoshitaka Konda and Michiaki Mishima

    Citation: Cough 2008 4:5

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  22. Content type: Research

    Because variable results of capsaicin challenges may be due to the incomplete solubility of capsaicin, we sought to determine if the use of Tween-80 in solutions of capsaicin improves actual concentrations of ...

    Authors: Scott E Kopec, Richard S Irwin, Ronald J DeBellis, Mark B Bohlke and Timothy J Maher

    Citation: Cough 2008 4:3

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  23. Content type: Research

    Involuntary coughing such as that evoked from the larynx, the laryngeal cough reflex (LCR), triggers a coordinated contraction of the thoracic, abdominal and pelvic muscles, which increases intra-abdominal pre...

    Authors: W Robert Addington, Robert E Stephens, Michael M Phelipa, John G Widdicombe and Robin R Ockey

    Citation: Cough 2008 4:2

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  24. Content type: Research

    Fifty spontaneously breathing pentobarbital-anesthetized cats were used to determine the incidence rate and parameters of short reflex expirations induced by mechanical stimulation of the tracheal mucosa (ERt)...

    Authors: Ivan Poliacek, Melanie J Rose, Lu Wen-Chi Corrie, Cheng Wang, Jan Jakus, Helena Barani, Albert Stransky, Hubert Polacek, Erika Halasova and Donald C Bolser

    Citation: Cough 2008 4:1

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  25. Content type: Research

    Cough reflex can be induced by the pepper extract capsaicin and by low pH in guinea-pig airways. Transient receptor potential vanniloid-1 (TPRV-1) is expressed in the sensory and afferent nerve fibres in airways.

    Authors: Sum Yee Leung, Akio Niimi, Alison S Williams, Puneeta Nath, F-Xavier Blanc, Q Thai Dinh and K Fan Chung

    Citation: Cough 2007 3:10

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  26. Content type: Research

    Many tussive agents are components of foods, but little is known about the relationship between cough reflex and oral chemesthesis sensitivities. We investigated the relationships between cough reflex and oral...

    Authors: Miyako Yamasaki, Satoru Ebihara, Takae Ebihara, Shannon Freeman, Shinsuke Yamanda, Masanori Asada, Motoki Yoshida and Hiroyuki Arai

    Citation: Cough 2007 3:9

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  27. Content type: Research

    Chronic cough is a common reason for presentation to both general practice and respiratory clinics. In up to 25% of cases, the cause remains unclear after extensive investigations. We report 4 patients present...

    Authors: Surinder S Birring, Alvin J Ing, Kevin Chan, Gavina Cossa, Sergio Matos, Michael DL Morgan and Ian D Pavord

    Citation: Cough 2007 3:7

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  28. Content type: Research

    Exposure to environmental tobacco smoke (ETS) and active tobacco smoking has been shown to increase symptoms of bronchial asthma such as bronchoconstriction but effects on other respiratory symptoms remain poo...

    Authors: Beatrix Groneberg-Kloft, Wojciech Feleszko, Quoc Thai Dinh, Anke van Mark, Elke Brinkmann, Dirk Pleimes and Axel Fischer

    Citation: Cough 2007 3:6

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  29. Content type: Research

    Chronic cough is a common symptom which causes significant levels of morbidity. It is becoming increasingly well characterised by research taking place in specialist cough clinics, where successful treatment r...

    Authors: Caroline F Everett, Jack A Kastelik, Rachel H Thompson and Alyn H Morice

    Citation: Cough 2007 3:5

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  30. Content type: Research

    Inflammatory mediators are involved in the pathogenesis of airway inflammation, but the role of prostaglandin I2 (PGI2) remains obscure. This study was designed to investigate the role of PGI2 in cough reflex ...

    Authors: Yoshihisa Ishiura, Masaki Fujimura, Kouichi Nobata, Yoshitaka Oribe, Miki Abo and Shigeharu Myou

    Citation: Cough 2007 3:2

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  31. Content type: Short report

    Gastro-oesophageal reflux (GOR) is one of the most common causes of chronic cough in Western countries, responsible for 10 to 40% of cases. In Japan, however, GOR-associated chronic cough (GOR-CC) has been rar...

    Authors: Hisako Matsumoto, Akio Niimi, Masaya Takemura, Tetsuya Ueda, Masafumi Yamaguchi, Hirofumi Matsuoka, Makiko Jinnai, Kazuo Chin and Michiaki Mishima

    Citation: Cough 2007 3:1

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  32. Content type: Research

    The relationships between chronic productive cough (CPC), environmental tobacco smoke (ETS) exposure, and asthma are not clearly established in children. Therefore, we wished to determine the prevalence of CPC...

    Authors: Edward R Carter, Jason S Debley and Gregory R Redding

    Citation: Cough 2006 2:11

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