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  1. Content type: Research

    Persistent dry cough is a well known unwanted effect of Angiotensin-Converting Enzyme inhibitors (ACE-i). Animal studies have shown that the ACE-i zofenopril has a less tussigenic effect compared to the widely...

    Authors: Federico Lavorini, Elisa Chellini, Margherita Innocenti, Giacomo Campi, Colin Gerard Egan, Selene Mogavero and Giovanni A Fontana

    Citation: Cough 2014 10:7

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  2. Content type: Research

    Chronic cough affects more than 70 percent of patients with Idiopathic Pulmonary Fibrosis and causes significant morbidity. Gastroesophageal reflux is the cause of some cases of chronic cough; and also has a p...

    Authors: Claire E Kilduff, Melanie J Counter, Gareth A Thomas, Nicholas K Harrison and Benjamin D Hope-Gill

    Citation: Cough 2014 10:4

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  3. Content type: Research

    A polymorphism (rs35705950) in the promoter region of the mucin MUC5B is associated with both familial and sporadic forms of idiopathic pulmonary fibrosis. (IPF) We hypothesize that this common MUC5B variant w...

    Authors: Mary Beth Scholand, Roger Wolff, Peter Fredrick Crossno, Krishna Sundar, Molly Winegar, Spencer Whipple, Patrick Carey, Nicholas Sunchild and Hilary Coon

    Citation: Cough 2014 10:3

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  4. Content type: Research

    Different conditions make the proximal airways susceptible to tussigenic stimuli in the chronic cough (CC) syndrome. Leukotrienes can be implicated in the inflammatory mechanism at play in it. Montelukast is a...

    Authors: Roxana K Mincheva, Tanya Z Kralimarkova, Miroslava Rasheva, Zlatko Dimitrov, Denislava Nedeva, Maria Staevska, Vera Papochieva, Penka Perenovska, Karina Bacheva, Vasil D Dimitrov and Todor A Popov

    Citation: Cough 2014 10:2

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  5. Content type: Research

    Chronic cough is a common and distressing symptom. Gastro-oesophageal reflux is a common cause of chronic cough however the symptom complex in cough is not confined to classic peptic symptoms. Dyspeptic sympto...

    Authors: Joanna Elizabeth Smith, Jaymin Bhagwanji Morjaria and Alyn Hugh Morice

    Citation: Cough 2013 9:27

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  6. Content type: Research

    The mechanisms of chronic cough are unclear. Many reactive oxygen species affect airway sensory C-fibres which are capable to induce cough. Several chronic lung diseases are characterised by cough and oxidativ...

    Authors: Heikki O Koskela and Minna K Purokivi

    Citation: Cough 2013 9:26

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  7. Content type: Research

    Obstructive sleep apnoea (OSA) has recently been identified as a possible aetiology for chronic cough. The aim of this study was to compare the incidence of chronic cough between patients with and without OSA ...

    Authors: Tsai-Yu Wang, Yu-Lun Lo, Wen-Te Liu, Shu-Min Lin, Ting-Yu Lin, Chih-Hsi Kuo, Fu-Tsai Chung, Pai-Chien Chou, Po-Jui Chang, Yung-Lun Ni, Shu-Chuan Ho, Horng-Chyuan Lin, Chun-Hua Wang, Chih-Teng Yu and Han-Pin Kuo

    Citation: Cough 2013 9:24

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  8. Content type: Review

    Altitude-related cough is a troublesome condition of uncertain aetiology that affects many visitors to high altitude. The traditionally held belief that it was due solely to the inspiration of cold, dry air wa...

    Authors: Nicholas P Mason

    Citation: Cough 2013 9:23

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  9. Content type: Research

    Non-pharmacological options for symptomatic management of cough are desired. Although chest wall mechanical vibration is known to ameliorate cough reflex sensitivity, the effect of mechanical vibrations on per...

    Authors: Naohiro Kashiwazaki, Satoru Ebihara, Peijun Gui, Norihiro Katayama, Kumiko Ito, Ryuhei Sato, Chika Oyama, Takae Ebihara and Masahiro Kohzuki

    Citation: Cough 2013 9:22

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  10. Content type: Review

    Various diseases often result in decompensation requiring resuscitation. In infantsmoderate hypoxia evokes a compensatory augmented breath – sigh and more severehypoxia results in a solitary gasp. Progressive ...

    Authors: Zoltan Tomori, Viliam Donic, Roman Benacka, Jan Jakus and Sona Gresova

    Citation: Cough 2013 9:21

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  11. Content type: Research

    Fentanyl-induced cough is usually mild and transitory, but it can be undesirable in patients with increased intracranial pressure, open wounds of the eye, dissecting aortic aneurism, pneumothorax, and reactive...

    Authors: Agreta Gecaj-Gashi, Zorica Nikolova-Todorova, Vlora Ismaili-Jaha and Musli Gashi

    Citation: Cough 2013 9:20

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  12. Content type: Review

    Cough is one of the most common complaints for which patients seek medical attention. Misdiagnosis and mistreatment of cough exist commonly in China. The prevalence of acute cough caused by upper airway infect...

    Authors: Kefang Lai, Jiayu Pan, Ruchong Chen, Baojuan Liu, Wei Luo and Nanshan Zhong

    Citation: Cough 2013 9:18

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  13. Content type: Review

    About 40% of the population will experience chronic cough at some point during their lives and it tends to be more common in women (Thorax 58:901–7, 2003). Post-nasal drip (or upper airway cough syndrome), gastro...

    Authors: Guri S Sandhu and Romana Kuchai

    Citation: Cough 2013 9:16

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  14. Content type: Research

    Many patients with chronic cough respond to treatment with inhaled corticosteroids but it is difficult to predict which patients are likely to respond. The primary aim of the present study was to define the ca...

    Authors: Heikki O Koskela and Minna K Purokivi

    Citation: Cough 2013 9:15

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  15. Content type: Review

    Chronic cough has been suggested to be due to three conditions, asthma, post nasal drip, and reflux disease. A different paradigm has evolved in which cough is viewed as the primary condition characterised by ...

    Authors: Alyn H Morice

    Citation: Cough 2013 9:14

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  16. Content type: Review

    There is an overwhelming body of evidence to support the existence of higher brain circuitries involved in the sensory detection of airways irritation and the motor control of coughing. The concept that cough ...

    Authors: Stuart B Mazzone, Alice E McGovern, Seung-Kwon Yang, Ariel Woo, Simon Phipps, Ayaka Ando, Jennifer Leech and Michael J Farrell

    Citation: Cough 2013 9:7

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  17. Content type: Research

    Chronic cough is one of the most challenging symptoms to diagnose and treat, not only because of the variety of underlying disorders but also its varying susceptibility to treatments. Etiological studies of ch...

    Authors: Hideyasu Shimizu, Masamichi Hayashi, Yuji Saito, Yuki Mieno, Yasuo Takeuchi, Fumihiko Sasaki, Hiroki Sakakibara, Kensei Naito and Mitsushi Okazawa

    Citation: Cough 2013 9:4

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  18. Content type: Research

    Although the mechanism of fentanyl-induced cough is unclear, several lines of evidence suggest that allergic mediators, such as histamine, may play a role in the production of fentanyl-induced coughs. The aim ...

    Authors: Junzo Kamei, Yuki Nakanishi, Megumi Asato and Hiroko Ikeda

    Citation: Cough 2013 9:3

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  19. Content type: Research

    Chronic cough is a common symptom the aetiology of which can be challenging to diagnose. Diagnostic protocols for chronic cough have required the use of specialist investigations which are not always easily av...

    Authors: Josephine C Ojoo, Caroline F Everett, Siobhain A Mulrennan, Shoaib Faruqi, Jack A Kastelik and Alyn H Morice

    Citation: Cough 2013 9:2

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  20. Content type: Research

    Cough, the most important airways defensive mechanism is modulated by many afferent inputs either from respiratory tussigenic areas, but also by afferent drive from other organs. In animal models, modulation o...

    Authors: Tomas Buday, Mariana Brozmanova, Zuzana Biringerova, Silvia Gavliakova, Ivan Poliacek, Vladimir Calkovsky, Manjunath V Shetthalli and Jana Plevkova

    Citation: Cough 2012 8:11

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  21. Content type: Case report

    Gastroesophageal reflux induced cough is a common cause of chronic cough, and proton pump inhibitors are a standard therapy. However, the patients unresponsive to the standard therapy are difficult to treat an...

    Authors: Xianghuai Xu, Qiang Chen, Siwei Liang, Hanjing LÜ and Zhongmin Qiu

    Citation: Cough 2012 8:8

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  22. Content type: Research

    Gastroesophageal reflux disease (GERD) is a common cause of chronic cough. Both acid and nonacid reflux is thought to play a role in the initiation of coughing and cough hypersensitivity. The GABAB receptor agoni...

    Authors: Brendan J Canning, Nanako Mori and Anders Lehmann

    Citation: Cough 2012 8:7

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  23. Content type: Case report

    Chronic cough is a common symptom carrying significant morbidity which can occur as a result of oesophageal dysmotility. Here we report 2 patients with musculoskeletal disease presenting with chronic cough to ...

    Authors: Sega Pathmanathan, Jaymin B Morjaria, Warren Jackson and Alyn H Morice

    Citation: Cough 2012 8:6

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  24. Content type: Research

    Viral respiratory tract infection is the most frequent cause of acute cough and is reported at onset in about one third of patients with chronic cough. Persistent infection is therefore one possible explanatio...

    Authors: Peter W West, Angela Kelsall, Samantha Decalmer, Winifred Dove, Paul W Bishop, James P Stewart, Ashley A Woodcock and Jaclyn A Smith

    Citation: Cough 2012 8:5

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  25. Content type: Research

    Airway reflux is a common cause of chronic cough and this is often refractory to medical therapy. Surgery in the form of Nissen fundoplication has been highly successful in the treatment of the classic reflux ...

    Authors: Shoaib Faruqi, Peter Sedman, Warren Jackson, Ian Molyneux and Alyn H Morice

    Citation: Cough 2012 8:3

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  26. Content type: Commentary

    This review dissects the complex human cough reflex and suggests hypotheses about the evolutionary basis for the reflex. A mechanosensory-induced cough reflex conveys through branches of myelinated Aδ nerve fi...

    Authors: Stuart M Brooks

    Citation: Cough 2011 7:10

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  27. Content type: Research

    To investigate differences between semi-recumbent and supine postures in terms of cough rate, oxygen desaturation, sedative use, and patient comfort during the initial phase of bronchoscopy.

    Authors: Ivan T Ling, Francesco Piccolo, Siobhain A Mulrennan and Martin J Phillips

    Citation: Cough 2011 7:9

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